Redox activation of Nrf2 & NF-κB: a double end sword?
M Buelna-Chontal, C Zazueta - Cellular signalling, 2013 - Elsevier
Moderate concentrations of reactive oxygen species (ROS) are produced by diverse sources
under physiological conditions. At such low levels, these molecules may act as upstream …
under physiological conditions. At such low levels, these molecules may act as upstream …
Mechanisms and control of pathologic bone loss in periodontitis.
The article explores the principal mechanisms of bone loss in periodontitis. The principal
feature of bone loss in this disease is enhanced osteoclast activity without a corresponding …
feature of bone loss in this disease is enhanced osteoclast activity without a corresponding …
[HTML][HTML] NF-κB in aging and disease
JS Tilstra, CL Clauson, LJ Niedernhofer… - Aging and …, 2011 - ncbi.nlm.nih.gov
Stochastic damage to cellular macromolecules and organelles is thought to be a driving
force behind aging and associated degenerative changes. However, stress response …
force behind aging and associated degenerative changes. However, stress response …
Zn0. 8Li0. 1Sr—a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: in vitro and in vivo studies
The first in vivo investigation of Zn-based biodegradable metal aiming to treat osteoporotic
bone fractures, a soaring threat to human health, is reported in this paper. Among the newly …
bone fractures, a soaring threat to human health, is reported in this paper. Among the newly …
ER stress, the unfolded protein response and osteoclastogenesis: a review
W Huang, Y Gong, L Yan - Biomolecules, 2023 - mdpi.com
Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein
response (UPR), are triggered by the accumulation of unfolded and misfolded proteins …
response (UPR), are triggered by the accumulation of unfolded and misfolded proteins …
[HTML][HTML] Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies
A novel biodegradable metal system, ZnLiCa ternary alloys, were systematically
investigated both in vitro and in vivo. The ultimate tensile strength (UTS) of Zn0. 8Li0. 1Ca …
investigated both in vitro and in vivo. The ultimate tensile strength (UTS) of Zn0. 8Li0. 1Ca …
Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review
L Wang, D Fang, J Xu, R Luo - BMC cancer, 2020 - Springer
Zoledronic acid (ZA) is one of the most important and effective class of anti-resorptive drug
available among bisphosphonate (BP), which could effectively reduce the risk of skeletal …
available among bisphosphonate (BP), which could effectively reduce the risk of skeletal …
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone
SK Custer, M Neumann, H Lu… - Human molecular …, 2010 - academic.oup.com
Inclusion body myopathy associated with Paget's disease of bone and frontotemporal
dementia (IBMPFD) is a dominantly inherited degenerative disorder caused by mutations in …
dementia (IBMPFD) is a dominantly inherited degenerative disorder caused by mutations in …
Novel functions for NFκB: inhibition of bone formation
NFκB is a family of transcription factors involved in immunity and the normal functioning of
many tissues. It has been well studied in osteoclasts, and new data indicate an important …
many tissues. It has been well studied in osteoclasts, and new data indicate an important …
NF-κB as a therapeutic target in inflammatory-associated bone diseases
Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue
homeostasis. In the skeletal system, inflammation is closely associated with many bone …
homeostasis. In the skeletal system, inflammation is closely associated with many bone …