The distinct contributions of fitness and genetic barrier to the development of antiviral drug resistance
M Götte - Current opinion in virology, 2012 - Elsevier
The selection of resistance to antiviral drugs depends on multiple parameters, including the
genetic barrier that is often broadly defined as the number of mutations required to …
genetic barrier that is often broadly defined as the number of mutations required to …
[HTML][HTML] Modified Nucleoside Triphosphates for In-vitro Selection Techniques
MA Dellafiore, JM Montserrat, AM Iribarren - Frontiers in Chemistry, 2016 - frontiersin.org
The development of SELEX (Selective Enhancement of Ligands by Exponential Enrichment)
provides a powerful tool for the search of functional oligonucleotides with the ability to bind …
provides a powerful tool for the search of functional oligonucleotides with the ability to bind …
Process for the production of 2-C-methyl-D-ribonolactone
R Storer, AM Moussa, N Chaudhuri… - US Patent …, 2009 - Google Patents
3 480 613 A 11/1969 Walton 3: 798: 209 A 3/1974 Wilkowski, 6161. CA 2252144'" 2000
3,891,623 A 6/1975 Vorbruggen et a1. 4,022,889 A 5/1977 Bannister et a1. 4,058,602 A …
3,891,623 A 6/1975 Vorbruggen et a1. 4,022,889 A 5/1977 Bannister et a1. 4,058,602 A …
Enzymatic recognition of 2′‐modified ribonucleoside 5′‐triphosphates: Towards the evolution of versatile aptamers
LH Lauridsen, JA Rothnagel, RN Veedu - ChemBioChem, 2012 - Wiley Online Library
The quest for effective, selective and nontoxic nucleic‐acid‐based drugs has led to
designing modifications of naturally occurring nucleosides. A number of modified nucleic …
designing modifications of naturally occurring nucleosides. A number of modified nucleic …
Methods and compositions for treating flaviviruses and pestiviruses
JP Sommadossi, P LaColla - US Patent 8,343,937, 2013 - Google Patents
(57) ABSTRACT A method and composition for treating a host infected with flavivirus or
pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a …
pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a …
Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus
J Deval, JA Symons, L Beigelman - Current opinion in virology, 2014 - Elsevier
Highlights•New therapies for infections caused by positive-strand RNA viruses are
needed.•Novel nucleoside and nucleotide analogs that inhibit HCV have been …
needed.•Novel nucleoside and nucleotide analogs that inhibit HCV have been …
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
P LaColla, R Storer, G Gosselin… - US Patent …, 2009 - Google Patents
2009-05-06 Assigned to UNIVERSITY OF CAGLIARI, L'UNIVERSITE MONTPELLIER II, THE
CENTRE NATIONAL DEL LA RECHERCHE SCIENTIFICQUE, IDENIX …
CENTRE NATIONAL DEL LA RECHERCHE SCIENTIFICQUE, IDENIX …
Identification of a pyridoxine-derived small-molecule inhibitor targeting dengue virus RNA-dependent RNA polymerase
HT Xu, SP Colby-Germinario… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The viral RNA-dependent RNA polymerase (RdRp) activity of the dengue virus (DENV) NS5
protein is an attractive target for drug design. Here, we report the identification of a novel …
protein is an attractive target for drug design. Here, we report the identification of a novel …
In vitro Selection of Resistance to Sofosbuvir in HCV Replicons of Genotype-1 to -6
S Xu, B Doehle, S Rajyaguru, B Han… - Antiviral …, 2017 - journals.sagepub.com
Background Sofosbuvir is a nucleoside analogue inhibitor of the HCV NS5B polymerase
approved for treatment of HCV-infected patients in combination with ribavirin or with other …
approved for treatment of HCV-infected patients in combination with ribavirin or with other …
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues
In targeting the essential viral RNA-dependent RNA-polymerase (RdRp), nucleotide
analogues play a major role in antiviral therapies. In the Flaviviridae family, the hepatitis C …
analogues play a major role in antiviral therapies. In the Flaviviridae family, the hepatitis C …