Computational study on the binding and unbinding mechanism of HCV NS5B with the inhibitor GS-461203 and substrate using conventional and steered molecular …
D Pan, Y Niu, L Ning, Y Zhang, H Liu, X Yao - Chemometrics and Intelligent …, 2016 - Elsevier
The active metabolite GS-461203 of hepatitis C virus (HCV) non-structural protein 5B
(NS5B) inhibitor sofosbuvir can stall RNA synthesis or replication by competitively inhibiting …
(NS5B) inhibitor sofosbuvir can stall RNA synthesis or replication by competitively inhibiting …
Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro
C Alotte, A Martin, SA Caldarelli, A Di Giorgio… - Antiviral research, 2008 - Elsevier
The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the
initiation of protein synthesis from viral RNA represents an ideal target for antisense …
initiation of protein synthesis from viral RNA represents an ideal target for antisense …
Genetic barrier and variant fitness in hepatitis C as critical parameters for drug resistance development
C Welsch - Drug Discovery Today: Technologies, 2014 - Elsevier
The approval of direct-acting antiviral agents (DAAs) has marked a pivotal change in the
treatment landscape of chronic hepatitis C. As for DAAs targeting other viral diseases, there …
treatment landscape of chronic hepatitis C. As for DAAs targeting other viral diseases, there …
Evaluation systems for anti-HCV drugs
K Moriishi, Y Matsuura - Advanced drug delivery reviews, 2007 - Elsevier
Development of therapeutics for chronic hepatitis C has been hampered by the lack of an
efficient cell culture system and a small animal model for the hepatitis C virus (HCV). An …
efficient cell culture system and a small animal model for the hepatitis C virus (HCV). An …
Synthesis, in vitro and in silico NS5B polymerase inhibitory activity of benzimidazole derivatives
VM Patil, G KR, M Chudayeu… - Medicinal …, 2012 - ingentaconnect.com
Hepatitis C virus (HCV) NS5B polymerase is the key replicating protein of the virus and thus
an attractive target for drug development. Here we report on the synthesis and biological …
an attractive target for drug development. Here we report on the synthesis and biological …
Transmission genetics of drug-resistant hepatitis C virus
Antiviral development is plagued by drug resistance and genetic barriers to resistance are
needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving …
needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving …
Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors
GC dinucleosides exhibiting a phosphoramidate internucleosidic linkage with neutral,
amphiphile, positively or negatively charged side chains were synthesized. Their potential …
amphiphile, positively or negatively charged side chains were synthesized. Their potential …
Resistance mechanisms in HCV: from evolution to intervention
AY Kim, J Timm - Expert Review of Anti-infective Therapy, 2008 - Taylor & Francis
Recent advances in our understanding of the HCV life cycle and the functions of virally
encoded proteins enabled the development of specifically targeted antiviral therapies for …
encoded proteins enabled the development of specifically targeted antiviral therapies for …
Emergence of genetically variant Hepatitis C virus population in response to increased antiviral drug pressure, Pakistan
Mutations in NS5B gene of Hepatitis C virus (HCV) have been reported in patients
undergoing antiviral therapy. In the present study, we report emerging clade of HCV-3a in …
undergoing antiviral therapy. In the present study, we report emerging clade of HCV-3a in …
Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women
PD Dryer, BN Limketkai, CM Martin… - Journal of …, 2009 - academic.oup.com
Abstract Objectives Hepatitis C virus (HCV) non-nucleoside inhibitors (NNIs) target the viral
RNA-dependent RNA polymerase encoded by the NS5B gene. Several NNIs share a similar …
RNA-dependent RNA polymerase encoded by the NS5B gene. Several NNIs share a similar …