Background White matter hyperintensities of presumed vascular origin (WMH) are one of the
imaging features of cerebral small vessel disease. Controversies persist about the effects of …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

Prevalence of dementia continues to increase because of the aging population and limited
treatment options. Cerebral small vessel disease and Alzheimer disease are the two most …

Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear
pathophysiology for AD has not been confirmed, and effective treatments are still not …

The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …

Hypoxia is a state of reduced oxygen supply and excessive oxygen consumption. According
to the duration of hypoxic period, it can be classified as acute and chronic hypoxia. Both …

Background CSF-soluble platelet-derived growth factor receptor beta (sPDGFRβ) is closely
associated with pericyte damage. However, the changes in CSF sPDGFRβ levels and their …

The treatment of neurodegenerative diseases is hindered by lack of interventions capable of
steering multimodal whole-brain dynamics towards patterns indicative of preserved brain …

Sex differences in mitochondrial numbers and function are present in large cerebral arteries,
but it is unclear whether these differences extend to the microcirculation. We performed an …