Surfactant protein D in respiratory and non-respiratory diseases

GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Human defensins and LL-37 in mucosal immunity

M Doss, MR White, T Tecle… - Journal of leukocyte …, 2010 - academic.oup.com
Defensins and LL-37 play key roles in maintaining mucosal barriers against invasive
infection and initiating immune responses after infection or injury to mucosal surfaces …

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

AM Grabiec, T Hussell - Seminars in immunopathology, 2016 - Springer
Acute and chronic inflammatory responses in the lung are associated with the accumulation
of large quantities of immune and structural cells undergoing apoptosis, which need to be …

Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD

DA Lomas, EK Silverman, LD Edwards… - European respiratory …, 2009 - Eur Respiratory Soc
Surfactant protein (SP)-D is a lung-derived protein that has been proposed as a biomarker
for inflammatory lung disease. Serum SP-D was evaluated as a biomarker for components of …

Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?

EFM Wouters, NL Reynaert, MA Dentener… - Proceedings of the …, 2009 - atsjournals.org
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) and
probably asthma are associated with low-grade systemic inflammatory changes. In patients …

Influenza virus N-linked glycosylation and innate immunity

IA York, J Stevens, IV Alymova - Bioscience reports, 2019 - portlandpress.com
Influenza viruses cause seasonal epidemics and sporadic pandemics in humans. The
virus's ability to change its antigenic nature through mutation and recombination, and the …

Interactions of α-, β-, and θ-defensins with influenza A virus and surfactant protein D

M Doss, MR White, T Tecle, D Gantz… - The Journal of …, 2009 - journals.aai.org
We have reported that the α-defensins human neutrophil peptides (HNP)-1 and HNP-2
neutralize and aggregate influenza A virus (IAV) and promote uptake of IAV by neutrophils …

Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation

A Haczku - Journal of Allergy and Clinical Immunology, 2008 - Elsevier
The acute inflammatory airway response is characterized by a time-dependent onset
followed by active resolution. Emerging evidence suggests that epithelial cells of the …

Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD

C Winkler, EN Atochina-Vasserman, O Holz… - Respiratory …, 2011 - Springer
Background Pulmonary surfactant protein D (SP-D) is considered as a candidate biomarker
for the functional integrity of the lung and for disease progression, which can be detected in …

Social stress and asthma: the role of corticosteroid insensitivity

A Haczku, RA Panettieri Jr - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
Psychosocial stress alters susceptibility to infectious and systemic illnesses and may
enhance airway inflammation in asthma by modulating immune cell function through neural …