Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-
function oxidases engaged in the biotransformation of physiologically relevant endobiotics …

Preclinical and clinical investigation on proteasome as a druggable target in cancer has led
to the development of proteasome inhibitors (PIs) with different pharmacodynamic and …

Chikungunya virus (CHIKV) is an alphavirus that causes a febrile illness accompanied by
myalgia and arthralgia. Despite having re-emerged as a significant public health threat …

Introduction Multiple myeloma (MM) is an increasingly treatable but still incurable
hematologic malignancy. Prognosis has improved significantly over recent years, although …

M3258 is the first selective inhibitor of the immunoproteasome subunit LMP7 (Large
multifunctional protease 7) in early clinical development with the potential to improve …

Targeting the proteome has become an increasingly important therapeutic strategy across a
variety of hematologic malignancies, but especially in those disease derived from …

Le protéasome est la principale machinerie de dégradation des protéines pour toutes les
cellules eucaryotes. Il est en effet impliqué dans une multitude de fonctions physiologiques …

Background: Compound kushen injection is increasingly used to treat various cancers.
However, its role in the management of multiple myeloma (MM) is still controversial and …