Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians

D Moris, M Palta, C Kim, PJ Allen… - CA: a cancer journal …, 2023 - Wiley Online Library
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and
remains a fatal malignancy in the majority of patients. Approximately 20%–30% of patients …

Immune microenvironment of cholangiocarcinoma: Biological concepts and treatment strategies

X Yu, L Zhu, T Wang, J Chen - Frontiers in Immunology, 2023 - frontiersin.org
Cholangiocarcinoma is characterized by a poor prognosis with limited treatment and
management options. Chemotherapy using gemcitabine with cisplatin is the only available …

Tucatinib and trastuzumab for previously treated human epidermal growth factor receptor 2–Positive metastatic biliary tract cancer (SGNTUC-019): a phase II basket …

Y Nakamura, N Mizuno, Y Sunakawa… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To evaluate the efficacy and safety of tucatinib and trastuzumab in patients with
previously treated human epidermal growth factor receptor 2–positive (HER2+) metastatic …

New era of immune-based therapy in intrahepatic cholangiocarcinoma

E Kawamura, T Matsubara, N Kawada - Cancers, 2023 - mdpi.com
Simple Summary Intrahepatic cholangiocarcinoma is the second most common primary liver
malignancy after hepatocellular carcinoma and accounts for 20% of biliary tract cancers. The …

Evolution of treatment in advanced cholangiocarcinoma: old and new towards precision oncology

M Capuozzo, M Santorsola, L Landi, V Granata… - International Journal of …, 2022 - mdpi.com
Cholangiocarcinoma (CCA) is a malignant neoplasm arising in the epithelium of the biliary
tract. It represents the second most common primary liver cancer in the world, after …

Immunotherapy as a Therapeutic Strategy for Gastrointestinal Cancer—Current Treatment Options and Future Perspectives

E Koustas, EM Trifylli, P Sarantis… - International Journal of …, 2022 - mdpi.com
Gastrointestinal (GI) cancer constitutes a highly lethal entity among malignancies in the last
decades and is still a major challenge for cancer therapeutic options. Despite the current …

Comparison of the effectiveness of chemotherapy combined with immunotherapy and chemotherapy alone in advanced biliary tract cancer and construction of the …

Z Zhang, D Wang, J Zhang, Y Ruan, L Zhao… - Cancer Immunology …, 2023 - Springer
Objective To analyze the effectiveness of combining immune checkpoint inhibitors (ICIs) with
first-line therapy in patients with advanced biliary tract cancer (BTC) and explore the …

Case Report: Camrelizumab combined with gemcitabine and oxaliplatin in the treatment of advanced intrahepatic cholangiocarcinoma: a case report and literature …

Z Zhang, X Wang, H Li, H Sun, J Chen… - Frontiers in …, 2023 - frontiersin.org
Intrahepatic cholangiocarcinoma (ICC) is one of the most common invasive malignant
tumors, with a 5-year survival rate of less than 5%. Currently, radical surgical resection is the …

Durvalumab in advanced cholangiocarcinoma: is someone knocking down the door?

AD Ricci, R D'Alessandro, A Rizzo, A Schirizzi… - …, 2023 - Taylor & Francis
Following the practice-changing results observed in several hematological and solid tumors,
immunotherapy with immune checkpoint inhibitors (ICIs) has been tested in …

Prognostic nutritional index associates with immunotherapy response in patients with metastatic biliary tract cancer

L Yang, J Zhong, W Wang, F Zhou - Nutrition and Cancer, 2023 - Taylor & Francis
Purpose: The present study aims to evaluate the effect of prognostic nutrition index (PNI) on
the response and prognosis of patients with metastatic biliary tract cancer (BTC) patients …