Brain organoid protocols and limitations

HH Zhao, G Haddad - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Stem cell-derived organoid technology is a powerful tool that revolutionizes the field of
biomedical research and extends the scope of our understanding of human biology and …

Autism Spectrum Disorder: Brain Areas Involved, Neurobiological Mechanisms, Diagnoses and Therapies

J Lamanna, J Meldolesi - International Journal of Molecular Sciences, 2024 - mdpi.com
Autism spectrum disorder (ASD), affecting over 2% of the pre-school children population,
includes an important fraction of the conditions accounting for the heterogeneity of autism …

Revolutionizing developmental neurotoxicity testing–A journey from animal models to advanced in vitro systems

L Smirnova, HT Hogberg, M Leist, T Hartung - ALTEX-Alternatives to …, 2024 - altex.org
Developmental neurotoxicity (DNT) testing has seen enormous progress over the last two
decades. Preceding even the publication of the animal-based OECD test guideline for DNT …

Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies

DB Pazzin, TTR Previato, JI Budelon Gonçalves… - Cells, 2024 - mdpi.com
This review delves into the groundbreaking impact of induced pluripotent stem cells (iPSCs)
and three-dimensional organoid models in propelling forward neuropathology research …

Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis

K Alam, L Nair, S Mukherjee, K Kaur, M Singh… - Bio-Design and …, 2024 - Springer
The microbiota–gut–brain axis (MGBA) has emerged as a key prospect in the bidirectional
communication between two major organ systems: the brain and the gut. Homeostasis …

Brain organoid protocols and limitations.

G Haddad, H Zhao - 2024 - escholarship.org
Stem cell-derived organoid technology is a powerful tool that revolutionizes the field of
biomedical research and extends the scope of our understanding of human biology and …

[PDF][PDF] AUTISM SPECTRUM DISORDER, MATERNAL IMMUNE ACTIVATION AND HUMAN INDUCED PLURIPOTENT STEM CELLS

MT Geheb - 2024 - duo.uio.no
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a wide
range of symptoms and varying degrees of severity. Understanding the underlying …

The Diagnostic Value of FGF-21 and GDF-15 as Biomarkers for Rare Childhood Mitochondrial Disorder Using Cerebral Organoids

R Peterson - 2023 - search.proquest.com
Mitochondrial disease is an umbrella term for a rare, clinically heterogenous group of
primary mitochondrial disorders, in which the affected tissues and organs have the highest …

[图书][B] Modeling FOXG1 Syndrome: Enhancing Model Accuracy and Biomimicry

S Iyer - 2023 - search.proquest.com
Disease modeling for neurodevelopmental disorders has long been a challenging
endeavor, necessitating innovative approaches to understand the underlying mechanisms …