[HTML][HTML] Natural polysaccharides for siRNA delivery: Nanocarriers based on chitosan, hyaluronic acid, and their derivatives

I Serrano-Sevilla, Á Artiga, SG Mitchell, L De Matteis… - Molecules, 2019 - mdpi.com
Natural polysaccharides are frequently used in the design of drug delivery systems due to
their biocompatibility, biodegradability, and low toxicity. Moreover, they are diverse in …

[HTML][HTML] Multifaceted applications of chitosan in cancer drug delivery and therapy

A Babu, R Ramesh - Marine drugs, 2017 - mdpi.com
Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and
biodegradable nature of chitosan, it is intensively utilized in biomedical applications in …

[HTML][HTML] Chitosan-based nanoparticles for nucleic acid delivery: technological aspects, applications, and future perspectives

M Karayianni, T Sentoukas, A Skandalis, N Pippa… - Pharmaceutics, 2023 - mdpi.com
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …

Nanodelivery of resveratrol-loaded PLGA nanoparticles for age-related macular degeneration

P Bhatt, G Fnu, D Bhatia, A Shahid, V Sutariya - AAPS PharmSciTech, 2020 - Springer
Age-related macular degeneration, precisely neovascular form, is the leading cause of
vision loss and the key treatment includes intravitreal injections of anti-vascular endothelial …

Production of low molecular weight chitosan by acid and oxidative pathways: Effect on physicochemical properties

BS de Farias, DDR Grundmann, FZ Rizzi… - Food Research …, 2019 - Elsevier
Chitosan–based biomaterials with a low molecular weight (LMW) have been drawn attention
due to the promising applications in the pharmaceutical and food fields. For this reason, the …

An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration

P Bhatt, P Narvekar, R Lalani, MB Chougule… - AAPS …, 2019 - Springer
Anti-vascular endothelial growth factor agents have been widely used to treat several eye
diseases including age-related macular degeneration (AMD). An approach to maximize the …

Lipid-nucleic acid nanoparticles of novel ionizable lipids for systemic BMP-9 gene delivery to bone-marrow mesenchymal stem cells for osteoinduction

I Vhora, R Lalani, P Bhatt, S Patil, A Misra - International journal of …, 2019 - Elsevier
Rational design of novel ionizable lipids for development of lipid-nucleic acid nanoparticles
(LNP) is required for safe and effective systemic gene delivery for osteoporosis. LNPs …

Fabrication of aptamer-guided siRNA loaded lipopolyplexes for gene silencing of notch 1 in MDA-mb-231 triple negative breast cancer cell line

L Gharaibeh, W Alshaer, S Wehaibi, R Al Buqain… - Journal of Drug Delivery …, 2021 - Elsevier
Triple negative breast cancer is an aggressive type of cancer with limited therapeutic
options. Aptamer-functionalized liposomes to deliver short interference RNAs (siRNAs) offer …

Co-delivery of cisplatin and siRNA through hybrid nanocarrier platform for masking resistance to chemotherapy in lung cancer

V Patel, R Lalani, I Vhora, D Bardoliwala… - Drug Delivery and …, 2021 - Springer
The resistance of cancer cells to chemotherapy has presented a formidable challenge. The
current research aims at evaluating whether silencing of the cisplatin efflux promoter gene …

Colloidally stable small unilamellar stearyl amine lipoplexes for effective BMP-9 gene delivery to stem cells for osteogenic differentiation

I Vhora, R Lalani, P Bhatt, S Patil, H Patel, V Patel… - AAPS …, 2018 - Springer
The biocompatibility of cationic liposomes has led to their clinical translation in gene delivery
and their application apart from cancer to cardiovascular diseases, osteoporosis, metabolic …