Ion channels and G protein–coupled receptors (GPCRs) are regulated by lipids in their
membrane environment. Structural studies combined with biophysical and molecular …

Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a
broad range of excitable and non-excitable cell types and are found in organisms ranging …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

Among the five KCNQ channels, also known as the K v 7 voltage-gated potassium (K v)
channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 …

Summary The KCNQ family (KCNQ1–KCNQ5) of voltage-gated potassium channels plays
critical roles in many physiological and pathological processes. It is known that the channel …

Background Prior studies have revealed remarkable phenotypic heterogeneity in KCNQ2-
related disorders, correlated with effects on biophysical features of heterologously …

Kv7 channels are enriched at the axonal plasma membrane where their voltage-dependent
potassium currents suppress neuronal excitability. Mutations in Kv7. 2 and Kv7. 3 subunits …

The delayed rectifier potassium IKs channel is an important regulator of the duration of the
ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) …

Zinc (Zn) is an essential trace element; it serves as a cofactor for a great number of enzymes,
transcription factors, receptors, and other proteins. Zinc is also an important signaling …

Calmodulin (CaM) and phosphatidylinositol 4, 5-bisphosphate (PIP2) are potent regulators
of the voltage-gated potassium channel KCNQ1 (KV7. 1), which conducts the cardiac I Ks …