Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management

PG Woodruff, A Agusti, N Roche, D Singh, FJ Martinez - The Lancet, 2015 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a common, complex, and heterogeneous
disorder that is responsible for substantial and growing morbidity, mortality, and health-care …

Asthma–COPD overlap syndrome (ACOS): a diagnostic challenge

NV Tho, HY Park, Y Nakano - Respirology, 2016 - Wiley Online Library
Asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is
characterized by persistent airflow limitation with several features usually associated with …

Comorbidome, pattern, and impact of asthma-COPD overlap syndrome in real life

JFM van Boven, M Roman-Rodriguez, JF Palmer… - Chest, 2016 - Elsevier
Background Asthma-COPD overlap syndrome (ACOS) has been described and
acknowledged as a distinct clinical entity; however, its characteristics in daily clinical …

Benralizumab: a unique IL-5 inhibitor for severe asthma

LD Tan, JM Bratt, D Godor, S Louie… - Journal of Asthma and …, 2016 - Taylor & Francis
The presence of eosinophilic inflammation is a characteristic feature of chronic and acute
inflammation in asthma. An estimated 5%–10% of the 300 million people worldwide who …

Asthma-COPD overlap syndrome: recent insights and unanswered questions

E Fouka, AI Papaioannou, G Hillas… - Journal of Personalized …, 2022 - mdpi.com
The term asthma-COPD overlap (ACO) has been used to identify a heterogeneous condition
in which patients present with airflow limitation that is not completely reversible and clinical …

Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study

LP Hayden, MH Cho, BA Raby, TH Beaty… - Respiratory …, 2018 - Springer
Background Childhood asthma is strongly influenced by genetics and is a risk factor for
reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This …

The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)

TE Albertson, JA Chenoweth, SJ Pearson… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a
disease phenotype that shares T helper lymphocyte cell Th1/neutrophilic/non-Type-2 …

Applying the wisdom of stepping down inhaled corticosteroids in patients with COPD: a proposed algorithm for clinical practice

AG Kaplan - … Journal of Chronic Obstructive Pulmonary Disease, 2015 - Taylor & Francis
Current guidelines for the management of chronic obstructive pulmonary disease (COPD)
recommend limiting the use of inhaled corticosteroids (ICS) to patients with more severe …

A proposal for the withdrawal of inhaled corticosteroids in the clinical practice of chronic obstructive pulmonary disease

M Miravitlles, BG Cosío, A Arnedillo, M Calle… - Respiratory …, 2017 - Springer
According to the current clinical practice guidelines for chronic obstructive pulmonary
disease (COPD), the addition of inhaled corticosteroids (ICS) to long-acting β 2 agonist …

Differential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients

X Huang, X Tan, Y Liang, C Hou, D Qu, M Li… - Scientific reports, 2019 - nature.com
Asthma-COPD overlap (ACO) has been under intensive focus; however, the levels of
damage-associated molecular patterns (DAMPs) that can activate the innate and adaptive …