Human organoids recapitulate the cell type diversity and function of their primary organs
holding tremendous potentials for basic and translational research. Advances in single‐cell …

Background Coronary artery disease (CAD) is a widespread heart condition caused by
atherosclerosis and influences millions of people worldwide. Early detection of CAD is …

Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a
leading cause of irreversible blindness worldwide. However, its molecular and cellular …

Methods that analyze single-cell paired RNA-seq and ATAC-seq multiome data have shown
great promise in linking regulatory elements to genes. However, existing methods differ in …

The heritability of human diseases is extremely enriched in candidate regulatory elements
(cRE) from disease-relevant cell types. Critical next steps are to infer which and how many …

Polygenic risk scores (PRSs) are commonly used for predicting an individual's genetic risk of
complex diseases. Yet, their implication for disease pathogenesis remains largely limited …

Background: Diabetic retinopathy (DR) is one of leading causes of vision loss in adults with
increasing prevalence worldwide. Increasing evidence has emphasized the importance of …

Pathway analysis is a crucial analytical phase in disease research on single-cell RNA
sequencing (scRNA-seq) data, offering biological interpretations based on prior knowledge …

Background: Single-cell multimodal techniques have advanced the functional elucidation of
disease-relevant loci identified in genome-wide association studies (GWASs). However, the …

Oxidative stress is a pivotal trigger of immune responses and cellular dysfunction. The
ruminant gastrointestinal tract (GIT) with complex microbial community demonstrated strong …