[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective
SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …
essential physiological process for the growth of cells, tissue repair, wound healing, and …
Revealing quinquennial anticancer journey of morpholine: A SAR based review
Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …
moiety of great significance. It forms an important intermediate in many industrial and …
In silico and in vitro studies for benzimidazole anthelmintics repurposing as VEGFR-2 antagonists: novel mebendazole-loaded mixed micelles with enhanced …
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers
Novel tolmetin derivatives 5a–f to 8a–c were designed, synthesised, and evaluated for
antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic …
antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic …
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxalin-4 (5H)-one and [1, 2, 4] triazolo [4,
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4 (3H)-ones as potential VEGFR-2 inhibitors
K El-Adl, AGA El-Helby, RR Ayyad, HA Mahdy… - Bioorganic & Medicinal …, 2021 - Elsevier
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus,
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …
Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …
Discovery of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation
IH Eissa, AGA El-Helby, HA Mahdy, MM Khalifa… - Bioorganic …, 2020 - Elsevier
Sixteen novel quinazoline-based derivatives were designed and synthesized via
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …
modification of the VEGFR-2 reported inhibitor 7 in order to increase the binding affinity of …
Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2, 4-dione derivatives targeting VEGFR-2 enzyme
Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
Political ties and corporate performance: why efficiency matters?
R Najaf, K Najaf - Journal of Business and Socio-Economic …, 2021 - emerald.com
Purpose The purpose of this paper is to examine and explain the complex interrelationships
which influence the performance of politically connected firms to create value for their …
which influence the performance of politically connected firms to create value for their …