MAPK-activated protein kinases: servant or partner?
N Ronkina, M Gaestel - Annual review of biochemistry, 2022 - annualreviews.org
Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are
defined by their exclusive activation by MAPKs. They can be activated by classical and …
defined by their exclusive activation by MAPKs. They can be activated by classical and …
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases
OA Olabisi, JY Zhang, L VerPlank… - Proceedings of the …, 2016 - National Acad Sciences
Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the
high rate of kidney disease in people of recent African ancestry. Expression in cultured cells …
high rate of kidney disease in people of recent African ancestry. Expression in cultured cells …
What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition
M Gaestel - Biological chemistry, 2013 - degruyter.com
Inflammation is normally a fast and transient response to microbial invaders or sterile
damage and has to be stringently controlled. The closely-related mitogen-activated protein …
damage and has to be stringently controlled. The closely-related mitogen-activated protein …
CRISPR, prime editing, optogenetics, and DREADDs: new therapeutic approaches provided by emerging technologies in the treatment of spinal cord injury
Spinal cord injury (SCI) causes temporary disabilities or permanent effects including
neuropathic pain and spastiscity. The damage often results from mechanical trauma, which …
neuropathic pain and spastiscity. The damage often results from mechanical trauma, which …
Heat shock proteins in the kidney
R Sreedharan, SK Van Why - Pediatric nephrology, 2016 - Springer
Heat shock proteins (Hsps) are essential to cell survival through their function as protein
chaperones. The role they play in kidney health and disease is varied. Hsp induction may be …
chaperones. The role they play in kidney health and disease is varied. Hsp induction may be …
High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis
Y Gao, N Jiang, X Qin, H Jiang, L Wei, J Gao - Genes & Genomics, 2023 - Springer
Abstract Background Circular RNAs (circRNAs), a unique novel type of RNA, have been
widely reported to be involved in physiologic and pathologic processes in humans …
widely reported to be involved in physiologic and pathologic processes in humans …
[PDF][PDF] 原发性肾病综合征的治疗机制研究进展
陈琪， 朱彩凤， 朱斌 - 温州医科大学学报, 2014 - xb.wmu.edu.cn
[1] Sheryanna A, Bhangal G, McDaid J, et al. Inhibition of p38 mitogen-activated protein
kinase is effective in the treatment of experimental crescentic glomerulonephritis and …
kinase is effective in the treatment of experimental crescentic glomerulonephritis and …
A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium
Inherited retinal dystrophies are clinically and genetically heterogeneous with significant
number of cases remaining genetically unresolved. We studied a large family from the West …
number of cases remaining genetically unresolved. We studied a large family from the West …
Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide
The p38MAPK downstream targets MAPKAP kinases (MK) 2 and 3 are critical for the
regulation of the macrophage response to LPS. The extents to which these two kinases act …
regulation of the macrophage response to LPS. The extents to which these two kinases act …
[HTML][HTML] MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection
K Köther, C Nordhoff, D Masemann, G Varga… - The FASEB …, 2014 - ncbi.nlm.nih.gov
MK2 and MK3 are downstream targets of p38 and ERK1/2. They control the mRNA stability
of several inflammatory cytokines, including TNF-α and IL-10. Whereas MK2 is expressed …
of several inflammatory cytokines, including TNF-α and IL-10. Whereas MK2 is expressed …