The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut
microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important …

Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause
of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota …

Colorectal cancer (CRC) is one of the most common cancers worldwide. As with other
cancers, CRC is a multifactorial disease due to the combined effect of genetic and …

Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone
mass and microarchitectural deterioration. Here, we show that warmth exposure (34° C) …

The gastrointestinal tract is a complex ecosystem that contains a large number of
microorganisms with different metabolic capacities. Modulation of the gut microbiome can …

The polyamines spermine, spermidine, and putrescine are involved in various biological
processes, notably in cell proliferation and differentiation, and also have antioxidant …

The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

Background The cross-talk between the host and its microbiota plays a key role in the
promotion of health. The production of metabolites such as polyamines by intestinal-resident …