FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that
restrict immune activation and are essential to prevent systemic autoimmunity. In the …

Chronic inflammation is a common factor linking various pathologies that differ in their
etiology and physiology such as cancer, autoimmune diseases, and infections. At a certain …

Chimeric antigen receptor (CAR) T cells can revolutionize cancer medicine. However,
overactivation, lack of tumor-specific surface markers, and antigen escape have hampered …

Migration of activated regulatory T (Treg) cells to inflamed tissue is crucial for their immune-
modulatory function. While metabolic reprogramming during Treg cell differentiation has …

Immune tolerance and activation depend on precise control over the number and function of
immunosuppressive Foxp3+ regulatory T (T reg) cells, and the importance of IL-2 in …

Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T
cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression …

Regulatory T cell (Treg) therapy has the potential to induce transplantation tolerance so that
immunosuppression and associated morbidity can be minimized. Alloantigen-reactive Tregs …

Acute graft-versus-host disease (GvHD) is a major cause of mortality in allogeneic bone
marrow transplantation (BMT), for which administration of FoxP3+ regulatory T (Treg) cells …

Expansion of human regulatory T cells (Tregs) for clinical applications offers great promise
for the treatment of undesirable immune responses in autoimmunity, transplantation, allergy …

Regulatory T cells (Tregs) play a central role in the induction and maintenance of immune
homeostasis and self-tolerance. Tregs constantly express the high-affinity receptor to IL-2. IL …