Cell-free DNA: hope and potential application in cancer
Y Yan, Q Guo, F Wang, R Adhikari, Z Zhu… - Frontiers in cell and …, 2021 - frontiersin.org
Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as
biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA …
biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA …
Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
U Testa, G Castelli, E Pelosi - Medicines, 2019 - mdpi.com
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
Genomic analysis of circulating tumor DNA in 3,334 patients with advanced prostate cancer identifies targetable BRCA alterations and AR resistance mechanisms
H Tukachinsky, RW Madison, JH Chung… - Clinical Cancer …, 2021 - AACR
Purpose: Comprehensive genomic profiling (CGP) is of increasing value for patients with
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …
Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer
M Kohli, W Tan, T Zheng, A Wang, C Montesinos… - …, 2020 - thelancet.com
Background Metastatic prostate cancer is a clonally heterogeneous disease state
characterized by progressive somatic perturbations. The aim of this study was to identify cell …
characterized by progressive somatic perturbations. The aim of this study was to identify cell …
Evolution of castration-resistant prostate cancer in ctDNA during sequential androgen receptor pathway inhibition
M Annala, S Taavitsainen, DJ Khalaf… - Clinical Cancer …, 2021 - AACR
Purpose: Cross-resistance renders multiple lines of androgen receptor (AR) signaling
inhibitors increasingly futile in metastatic castration-resistant prostate cancer (mCRPC). We …
inhibitors increasingly futile in metastatic castration-resistant prostate cancer (mCRPC). We …
Treatment-driven tumour heterogeneity and drug resistance: Lessons from solid tumours
Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its
dynamics and continuous changes under external pressure, it is one of the major causes of …
dynamics and continuous changes under external pressure, it is one of the major causes of …
Cancer stem cell in prostate cancer progression, metastasis and therapy resistance
P Verma, N Shukla, S Kumari, MS Ansari… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Prostate cancer (PCa) is the most diagnosed malignancy in the men worldwide. Cancer
stem cells (CSCs) are the sub-population of cells present in the tumor which possess unique …
stem cells (CSCs) are the sub-population of cells present in the tumor which possess unique …
[HTML][HTML] Predicting patient-specific response to adaptive therapy in metastatic castration-resistant prostate cancer using prostate-specific antigen dynamics
Abiraterone acetate (AA) has been proven effective for metastatic castration-resistant
prostate cancer (mCRPC), and it has been proposed that adaptive AA may reduce toxicity …
prostate cancer (mCRPC), and it has been proposed that adaptive AA may reduce toxicity …
Combined cell-free DNA and RNA profiling of the androgen receptor: clinical utility of a novel multianalyte liquid biopsy assay for metastatic prostate cancer
Background The androgen receptor (AR) remains a critical driver in metastatic castration-
resistant prostate cancer (mCRPC). Profiling AR aberrations in both circulating DNA and …
resistant prostate cancer (mCRPC). Profiling AR aberrations in both circulating DNA and …
Clinical utility of emerging biomarkers in prostate cancer liquid biopsies
E Boerrigter, LN Groen, NP Van Erp… - Expert review of …, 2020 - Taylor & Francis
ABSTRACT Introduction: Prostate cancer (PCa) is one of the most common malignancies in
men and a major cause of cancer deaths among men worldwide. Prostate specific antigen …
men and a major cause of cancer deaths among men worldwide. Prostate specific antigen …