Importance Hypoxic-ischemic encephalopathy (HIE) occurs in 1 to 8 per 1000 live births in
developed countries. Historically, the clinician has had little to offer neonates with HIE other …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Background: Intrapartum hypoxic events (“birth asphyxia”) may result in stillbirth, neonatal or
postneonatal mortality, and impairment. Systematic morbidity estimates for the burden of …

Interruption of blood flow and gas exchange to the fetus in the perinatal period, known as
perinatal asphyxia, can, if significant, trigger a cascade of neuronal injury, leading on to …

Importance Therapeutic hypothermia reduces risk of death and disability in infants with
moderate to severe hypoxic ischemic encephalopathy (HIE). Randomized clinical trials of …

Aims Hypoxic ischaemic encephalopathy (HIE) remains a significant cause of long term
neurodisability despite therapeutic hypothermia (TH). Infants with mild HIE, representing …

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

Hypoxic‐ischaemic damage to the developing brain is a leading cause of child death, with
high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities …

Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates
with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few …