Chronic pain represents one of the most important public health problems and, in addition to
classical analgesics, antidepressants are an essential part of the therapeutic strategy. This …

OBJECTIVE: While guidelines for treating patients with bipolar depression recommend
discontinuing antidepressants within 6 months after remission, few studies have assessed …

Background: The possibility that antidepressant drugs, while effectively treating depression,
may worsen its course has received inadequate attention. Method: A review of the literature …

Introduction Dapoxetine has been evaluated for the on-demand treatment of premature
ejaculation (PE) in five phase 3 studies in various populations worldwide and has recently …

Background: The Canadian Psychiatric Association and the Canadian Network for Mood
and Anxiety Treatments partnered to produce clinical guidelines for psychiatrists for the …

OBJECTIVE: To establish specific criteria by which selective serotonin reuptake inhibitor
(SSRI) discontinuation syndrome may be identified. DATA SOURCES: MEDLINE and …

The effects of an abrupt interruption of agomelatine, a new melatonergic/serotonergic
antidepressant, were explored in a double-blind, placebo-controlled study. Paroxetine was …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• In recent years there has been
concern regarding the possibility that selective serotonin reuptake inhibitors (SSRIs) cause …

There is increasing awareness that, in some cases, long-term use of antidepressant drugs
(AD) may enhance the biochemical vulnerability to depression and worsen its long-term …

Strong evidence supports the existence of a discontinuation syndrome following the
withdrawal of antidepressant medication, particularly second-generation antidepressants …