Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related …

A Kobrina, KM Schrode, LA Screven, H Javaid… - Neurobiology of …, 2020 - Elsevier
Age-related hearing loss is a very common sensory disability, affecting one in three older
adults. Establishing a link between anatomical, physiological, and behavioral markers of …

Redox imbalance as a common pathogenic factor linking hearing loss and cognitive decline

F Paciello, C Ripoli, AR Fetoni, C Grassi - Antioxidants, 2023 - mdpi.com
Experimental and clinical data suggest a tight link between hearing and cognitive functions
under both physiological and pathological conditions. Indeed, hearing perception requires …

Age-related changes in neural coding of envelope cues: peripheral declines and central compensation

A Parthasarathy, EL Bartlett, SG Kujawa - Neuroscience, 2019 - Elsevier
Aging listeners often experience difficulties in perceiving temporally complex acoustic cues
in noisy environments. These difficulties likely have neurophysiological contributors from …

Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve

G Encina-Llamas, JM Harte, T Dau… - Journal of the …, 2019 - Springer
The healthy auditory system enables communication in challenging situations with high
levels of background noise. Yet, despite normal sensitivity to pure tones, many listeners …

Enhanced central neural gain compensates acoustic trauma-induced cochlear impairment, but unlikely correlates with tinnitus and hyperacusis

D Möhrle, B Hofmeier, M Amend, S Wolpert, K Ni… - Neuroscience, 2019 - Elsevier
For successful future therapeutic strategies for tinnitus and hyperacusis, a subcategorization
of both conditions on the basis of differentiated neural correlates would be of invaluable …

Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis

D Na, J Zhang, HJ Beaulac… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's Disease (AD) is a neurodegenerative illness without a cure. All current therapies
require an accurate diagnosis and staging of AD to ensure appropriate care. Central …

[HTML][HTML] Disturbed balance of inhibitory signaling links hearing loss and cognition

M Knipper, W Singer, K Schwabe… - Frontiers in Neural …, 2022 - frontiersin.org
Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory
activity is associated with numerous forms of hearing loss, including noise damage, age …

Central compensation in auditory brainstem after damaging noise exposure

KM Schrode, MA Muniak, YH Kim, AM Lauer - ENeuro, 2018 - eneuro.org
Noise exposure is one of the most common causes of hearing loss and peripheral damage
to the auditory system. A growing literature suggests that the auditory system can …

Neural signatures of temporal regularity processing in sounds differ between younger and older adults

B Herrmann, C Buckland, IS Johnsrude - Neurobiology of Aging, 2019 - Elsevier
Sensitivity to temporal regularity (eg, recurring modulation in amplitude) is crucial for speech
perception. Degradation of the auditory periphery due to aging and hearing loss may lead to …

Aging alters envelope representations of speech-like sounds in the inferior colliculus

A Parthasarathy, B Herrmann, EL Bartlett - Neurobiology of aging, 2019 - Elsevier
Hearing impairment in older people is thought to arise from impaired temporal processing in
auditory circuits. We used a systems-level (scalp recordings) and a microcircuit-level …