Mild cognitive impairment (MCI), first fully characterized by Petersen and associates in 1997,
1 generally refers to impairment in cognition above that which is seen with normal age …

Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

Glucose transporters (GLUTs) at the blood-brain barrier maintain the continuous high
glucose and energy demands of the brain. They also act as therapeutic targets and provide …

Positron emission tomography (PET) imaging is based on detecting two time-coincident high-
energy photons from the emission of a positron-emitting radioisotope. The physics of the …

Objectives The aim of this article was to review the current role of brain PET in the diagnosis
of Alzheimer dementia. The characteristic patterns of glucose metabolism on brain FDG-PET …

Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a
heterogeneous neurodegenerative disease characterized by progressive behavioural …

Alzheimer's disease (AD) is a heterogeneous progressive neurocognitive disorder. Although
different neuroimaging modalities have been used for the identification of early diagnostic …

The purpose of this article is to present a selective and concise summary of
fluorodeoxyglucose (FDG) positron emission tomography (PET) in dementia imaging. FDG …

Dementia, a chronic and progressive cognitive declination of brain function caused by
disease or impairment, is becoming more prevalent due to the aging population. A major …

O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification,
occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation …