Khellin is the key furanocoumarin of Ammi visnaga L.(Lam.) that exhibits various biological
properties. This unique natural product has inspired the discovery of two first-in-class drugs …

A drug interaction occurs when the pharmacological effects of the object drug alters the
intensity of the precipitant drug. Whenever two or more drugs are taken concurrently there is …

The tissue distribution and hepatic microsomal metabolism of amiodarone were studied in a
hyperlipidemic rat model. Rats were rendered hyperlipidemic by the intraperitoneal injection …

Drug‐induced liver injury (DILI) is the most frequent cause of post‐marketing warnings and
withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans …

The purpose of the experiment was mainly to establish and verify a precise and
straightforward ultra-performance liquid chromatography tandem mass spectrometry (UPLC …

The pharmacokinetics of desethylamiodarone (DEA), the active metabolite of amiodarone
(AM), were studied in the rat after administration of AM or preformed metabolite. Rats …

A rapid and sensitive high-performance liquid chromatography (HPLC) method was
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …

A stable isotope dilution liquid chromatography–electrospray ionization tandem mass
spectrometry (LC–MS/MS) assay to measure amiodarone, the most frequently used agent …

To assess the influence of hyperlipidemia (HL) on amiodarone (AM) effect in the heart, rats
were pretreated with either 1 g/kg poloxamer 407 (to induce HL) or saline intraperitoneally …

Amiodarone is a potent antiarrhythmic drug with several limiting side effects, some of which
have been correlated with increased levels of its more toxic metabolite …