Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms
and testing interventions and therapeutics. For disorders such as Alzheimer's disease in …

Recent successive approval of anti-amyloid-β (Aβ) monoclonal antibodies as disease-
modifying therapies against Alzheimer's disease (AD) has raised great confidence in the …

Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …

Efficient therapeutic strategies that concurrently target both Aβ aggregation and oxidative
stress in the Alzheimer's disease (AD) microenvironment emerge as a cutting‐edge tool to …

Background An active lifestyle is associated with improved cognitive functions in aged
people and may prevent or slow down the progression of various neurodegenerative …

Increasing evidence supports that age, APOE and sex interact to modulate Alzheimer's
disease (AD) risk, however the underlying pathways are unclear. One way that AD risk …

Meta-analysis of genome-wide association study data has implicated PDE4B in the
pathogenesis of Alzheimer's disease (AD), the leading cause of senile dementia. PDE4B …

Education, occupation, and an active lifestyle, comprising enhanced social, physical, and
mental components are associated with improved cognitive functions in aged people and …

Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the
underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to …

Introduction Dysfunction of the cerebral vasculature is considered one of the key
components of Alzheimer's disease (AD), but the mechanisms affecting individual brain …