Pharmaceutical nanocrystals: production by wet milling and applications
Highlights•Nanocrystals are nanosized drug particles produced in the form of
nanosuspensions.•Nanocrystals are an industrially feasible formulation for poorly soluble …
nanosuspensions.•Nanocrystals are an industrially feasible formulation for poorly soluble …
Emerging role of nanosuspensions in drug delivery systems
Rapid advancement in drug discovery process is leading to a number of potential new drug
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …
[HTML][HTML] Spray drying for the preparation of nanoparticle-based drug formulations as dry powders for inhalation
Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance
delivery of poorly water-soluble drugs, protect drugs against degradation and achieve …
delivery of poorly water-soluble drugs, protect drugs against degradation and achieve …
Production of pure drug nanocrystals and nano co-crystals by confinement methods
The use of drug nanocrystals in the drug formulation is increasing due to the large number of
poorly water-soluble drug compounds synthetized and due to the advantages brought by the …
poorly water-soluble drug compounds synthetized and due to the advantages brought by the …
[HTML][HTML] Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications
Advancements in in silico techniques of lead molecule selection have resulted in the failure
of around 70% of new chemical entities (NCEs). Some of these molecules are getting …
of around 70% of new chemical entities (NCEs). Some of these molecules are getting …
Impact of trehalose on physicochemical stability of β-carotene high loaded microcapsules fabricated by wet-milling coupled with spray drying
Solvent-free β-carotene high loaded microcapsules formulated by octenyl succinic
anhydride (OSA)-starch and trehalose were prepared by a combination of wet-milling and …
anhydride (OSA)-starch and trehalose were prepared by a combination of wet-milling and …
Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling
The aim of this study is to develop nanosuspension of carvedilol (CRV) by wet media milling.
Concentration of polymeric stabilizer (hydroxypropyl cellulose-HPC-SL), milling speed and …
Concentration of polymeric stabilizer (hydroxypropyl cellulose-HPC-SL), milling speed and …
Formulation and optimization of lyophilized nanosuspension tablets to improve the physicochemical properties and provide immediate release of silymarin
AH Ibrahim, E Rosqvist, JH Smått, HM Ibrahim… - International journal of …, 2019 - Elsevier
Silymarin (SLM) is a hepatoprotective herbal drug characterized by low aqueous solubility
and, consequently, low oral bioavailability. The objective of this study was to enhance the …
and, consequently, low oral bioavailability. The objective of this study was to enhance the …
[HTML][HTML] The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin
B Shen, C Shen, W Zhu, H Yuan - Acta Pharmaceutica Sinica B, 2021 - Elsevier
In this study, self-discriminating hybrid nanocrystals was utilized to explore the biological
fate of quercetin hybrid nanocrystals (QT-HNCs) with diameter around 280 nm (QT-HNCs …
fate of quercetin hybrid nanocrystals (QT-HNCs) with diameter around 280 nm (QT-HNCs …
[HTML][HTML] A review on solubility enhancement methods for poorly water-soluble drugs
A Ainurofiq, DS Putro, DA Ramadhani… - Journal of Reports in …, 2021 - journals.lww.com
One of the most important parameters in pharmacy is drug solubility. Solubility affects the
efficacy of a drug. Drug solubility has an important role in determining the concentration of a …
efficacy of a drug. Drug solubility has an important role in determining the concentration of a …