Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

The muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle
and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG …

Stress fibers (SFs) are often the most prominent cytoskeletal structures in cells growing in
tissue culture. Composed of actin filaments, myosin II, and many other proteins, SFs are …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

Cancer cell metastasis is a multi-stage process involving invasion into surrounding tissue,
intravasation, transit in the blood or lymph, extravasation, and growth at a new site. Many of …

Apoptosis is an important biological process required for the removal of unwanted or
damaged cells. Mounting evidence implicates the actin cytoskeleton as both a sensor and …

Tropomyosins are rodlike coiled coil dimers that form continuous polymers along the major
groove of most actin filaments. In striated muscle, tropomyosin regulates the actin-myosin …

Cell polarity relies on the asymmetric organization of cellular components and structures.
Actin and microtubules are well suited to provide the structural basis for cell polarization …

Regulated tissue invasion via motile and lytic events is critical for physiological processes
such as immune system function and inflammatory responses, wound healing, and organ …