Quality and quantity control of gene expression by nonsense-mediated mRNA decay
T Kurosaki, MW Popp, LE Maquat - Nature reviews Molecular cell …, 2019 - nature.com
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …
[HTML][HTML] Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty
C Badowski, B He, LX Garmire - NPJ precision oncology, 2022 - nature.com
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …
[HTML][HTML] Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Abstract The chr12q24. 13 locus encoding OAS1–OAS3 antiviral proteins has been
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases
The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs
bearing premature termination codons (PTCs). Decades of work have elucidated the …
bearing premature termination codons (PTCs). Decades of work have elucidated the …
Alternative ORFs and small ORFs: shedding light on the dark proteome
Traditional annotation of protein-encoding genes relied on assumptions, such as one open
reading frame (ORF) encodes one protein and minimal lengths for translated proteins. With …
reading frame (ORF) encodes one protein and minimal lengths for translated proteins. With …
[HTML][HTML] Six reference-quality genomes reveal evolution of bat adaptations
Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …
and unique immunity. High-quality genomes are crucial for understanding the molecular …
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice
Gene therapy is a potentially curative medicine for many currently untreatable diseases, and
recombinant adeno-associated virus (rAAV) is the most successful gene delivery vehicle for …
recombinant adeno-associated virus (rAAV) is the most successful gene delivery vehicle for …
GC content shapes mRNA storage and decay in human cells
mRNA translation and decay appear often intimately linked although the rules of this
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …
Translation‐coupled mRNA quality control mechanisms
L Monaghan, D Longman, JF Cáceres - The EMBO Journal, 2023 - embopress.org
Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
[HTML][HTML] Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer
The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …
progression of solid tumors remains to be defined. Here we describe the first comprehensive …