Mast cells as sources of cytokines, chemokines, and growth factors
Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …
represent potential sources of a wide variety of biologically active secreted products …
G1 Events and Regulation of Cell Proliferation
AB Pardee - Science, 1989 - science.org
Cells prepare for S phase during the G1 phase of the cell cycle. Cell biological methods
have provided knowledge of cycle kinetics and of substages of G1 that are determined by …
have provided knowledge of cycle kinetics and of substages of G1 that are determined by …
The stress-activated protein kinase subfamily of c-Jun kinases
JM Kyriakis, P Banerjee, E Nikolakaki, T Dai, EA Rubie… - Nature, 1994 - nature.com
THE mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases
that are themselves activated through concomitant phosphorylation of tyrosine and …
that are themselves activated through concomitant phosphorylation of tyrosine and …
Tumor necrosis factor-alpha expression in ischemic neurons.
T Liu, RK Clark, PC McDonnell, PR Young, RF White… - Stroke, 1994 - Am Heart Assoc
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with diverse proinflammatory actions,
including endothelial leukocyte adhesion molecule expression. Since leukocytes infiltrate …
including endothelial leukocyte adhesion molecule expression. Since leukocytes infiltrate …
A novel domain within the 55 kd TNF receptor signals cell death
LA Tartaglia, TM Ayres, GHW Wong, DV Goeddel - Cell, 1993 - cell.com
Deletion mutagenesis of the intracellular region of the 55 kd TNF receptor (TNF-Rl) identified
an-80 amino acid domain near the C-terminus responsible for signaling cytotoxicity. This …
an-80 amino acid domain near the C-terminus responsible for signaling cytotoxicity. This …
Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin
TUMOUR necrosis factor-α (TNF-α)/cachectin is a multifunctional cytokine that has effects in
inflammation, sepsis, lipid and protein metabolism, haematopoiesis, angiogenesis and host …
inflammation, sepsis, lipid and protein metabolism, haematopoiesis, angiogenesis and host …
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
M Rothe, SC Wong, WJ Henzel, DV Goeddel - Cell, 1994 - cell.com
Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmlc
domain of the human 75 kDa tumor necrosis factor receptor (TNFR2) that Is required for …
domain of the human 75 kDa tumor necrosis factor receptor (TNFR2) that Is required for …
Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.
AN Shakhov, MA Collart, P Vassalli… - The Journal of …, 1990 - rupress.org
We have explored the cis-acting elements necessary for the LPS-mediated activation of the
mouse TNF-alpha promoter by transfecting a set of 5'deletion mutants linked to the CAT …
mouse TNF-alpha promoter by transfecting a set of 5'deletion mutants linked to the CAT …
Two TNF receptors
LA Tartaglia, DV Goeddel - Immunology today, 1992 - cell.com
Tumor necrosis factor (TNF), a potent cytokine produced mainly by activated macrophages,
has numerous biological functions, including hemorrhagic necrosis of transplanted tumors …
has numerous biological functions, including hemorrhagic necrosis of transplanted tumors …
The two different receptors for tumor necrosis factor mediate distinct cellular responses.
LA Tartaglia, RF Weber, IS Figari… - Proceedings of the …, 1991 - National Acad Sciences
The individual roles of the murine type 1 and type 2 tumor necrosis factor (TNF) receptors
(TNF-R1 and TNF-R2) were investigated utilizing (i) the strong species specificity of TNF-R2 …
(TNF-R1 and TNF-R2) were investigated utilizing (i) the strong species specificity of TNF-R2 …