Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

The hippocampus has been implicated in modulating anxiety. It interacts with a variety of
brain regions, both cortical and subcortical areas regulating emotion and stress responses …

There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Epilepsy is a common disease of the nervous system characterized by transient brain
dysfunction caused by an abnormal electrical discharge from the brain neurons. The …

Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal
lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this …

Epilepsy is a devastating brain disorder for which effective treatments are very limited. There
is growing interest in early intervention, which requires a better mechanistic understanding …

The dentate gyrus (DG) of the hippocampus is important for cognition and behavior.
However, the circuits underlying these functions are unclear. DG mossy cells (MCs) are …

Mossy cells (MCs) of the dentate gyrus (DG) are a major group of excitatory hilar neurons
that are important for regulating activity of dentate granule cells. MCs are particularly …

Temporal lobe epilepsy (TLE) is thought to be associated with neuronal hyperexcitability in
the hippocampal-entorhinal cortical (EC) circuit. Due to the complexity of the hippocampal …

The hippocampal CA2 region, an area important for social memory, has been suspected to
play a role in temporal lobe epilepsy (TLE) because of its resistance to degeneration …