Cell death by apoptosis and permanent cell cycle arrest by senescence serve as barriers to
the development of cancer. Chemotherapeutic agents not only induce apoptosis, they can …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Breast cancer cells must avoid intrinsic and extrinsic cell death to relapse following
chemotherapy. Entering senescence enables survival from mitotic catastrophe, apoptosis …

Cellular senescence is characterized as a stable proliferation arrest that can be triggered by
multiple stresses. Most knowledge about senescent cells is obtained from studies in primary …

Tumor cells undergo senescence in response to both conventional and targeted cancer
therapies. The induction of senescence in response to cancer therapy can contribute to …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Simple Summary Senescence is an essential component of tumor cell biology and is a
primary cell stress response to therapy. While the long-term impact of senescence in cancer …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Senolytics, drugs that kill senescent cells, have been proposed to improve the response to
pro-senescence cancer therapies; however, this remains challenging due to a lack of …