Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting
enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be …

Persistent inflammatory response has adverse effects on left ventricular (LV) function and
remodeling following acute myocardial infarction. We hypothesized that suppression of …

The increasing prevalence of heart failure poses enormous challenges for health care
systems worldwide. Despite effective medical interventions that target neurohumoral …

Cardiac fibrosis is one of the major components of the healing mechanism following any
injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a …

Cells sense mechanical stress and changes in their matrix environment through the
integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands …

Cardiac fibrosis is a common finding that is associated with the progression of heart failure
(HF) and impacts all chambers of the heart. Despite intense research, the treatment of HF …

The protein sarcospan (SSPN) is an integral member of the dystrophin-glycoprotein complex
(DGC) and has been shown to be important in the heart during the development and the …

Continuous contraction–relaxation cycles of the heart require strong and stable connections
of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal …