Melatonin and its metabolites as chemical agents capable of directly repairing oxidized DNA

A Pérez‐González, R Castañeda‐Arriaga… - Journal of pineal …, 2019 - Wiley Online Library
Oxidative stress mediates chemical damage to DNA yielding a wide variety of products. In
this work, the potential capability of melatonin and several of its metabolites to repair directly …

Melatonin: A smart molecule in the DNA repair system

SM Mir, A Aliarab, G Goodarzi… - Cell Biochemistry …, 2022 - Wiley Online Library
DNA repair is an important pathway for the protection of DNA molecules from destruction.
DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation …

[HTML][HTML] Melatonin as a harmonizing factor of circadian rhythms, neuronal cell cycle and neurogenesis: additional arguments for its therapeutic use in Alzheimer's …

M Shukla, B Vincent - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
The synthesis and release of melatonin in the brain harmonize various physiological
functions. The apparent decline in melatonin levels with advanced aging is an aperture to …

Molecular docking, molecular dynamics, MM/PBSA approaches and bioactivity studies of nepetanudoside B isolated from endemic Nepeta aristata

Y Başar, İ Demirtaş, S Yenigün, Y İpek… - Journal of …, 2024 - Taylor & Francis
Nepetanudoside B (NNB) was isolated from aerial parts of endemic Nepeta aristata crude
extract (CH3OH-CHCl3) using silica gel (n-hexane, methanol, ethyl acetate, and …

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

AS Naidu, CK Wang, P Rao, F Mancini… - npj Science of …, 2024 - nature.com
Abstract SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic
capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic …

Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective

M Sharifi, NR Nikoo, B Badehnoosh… - … -Research and Practice, 2023 - Elsevier
Endometriosis, the very serious disease in women creates a huge financial burden
worldwide, which is comparable to diabetes mellitus. In addition to the typical pelvic pain …

Neurotoxicity of bisphenol A and the impact of melatonin administration on oxidative stress, ERK/NF-kB signaling pathway, and behavior in rats

AC Sevastre-Berghian, C Casandra, D Gheban… - Neurotoxicity …, 2022 - Springer
Bisphenol A (BPA) exposure can be associated with neurodevelopmental disorders due to
impairment of cell proliferation and synaptic development. Our study evaluated the effects of …

Mitochondrial melatonin: beneficial effects in protecting against heart failure

RJ Reiter, R Sharma, LGA Chuffa, F Simko… - Life, 2024 - mdpi.com
Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually.
Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy …

Potential neuroprotective role of melatonin in sepsis-associated encephalopathy due to its scavenging and anti-oxidative properties

M Sieminski, K Szaruta-Raflesz, J Szypenbejl… - Antioxidants, 2023 - mdpi.com
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. The brain is one of the organs involved in sepsis, and sepsis-induced …

Coadministration of melatonin and insulin improves diabetes-induced impairment of rat kidney function

YA Hajam, S Rai, SR Pandi-Perumal, GM Brown… - …, 2022 - karger.com
Introduction: The present study was designed to evaluate the therapeutic efficacy of
melatonin and insulin coadministration in diabetes-induced renal injury in rats. Research …