Simple Summary One of the most frequently diagnosed cancer in men is adenocarcinoma of
the prostate. Once the disease is metastatic, only very limited treatment options are …

The sequence similarity within the amino‐terminal regions of parathyroid hormone (PTH)
and PTH‐related protein (PTHrP) allows the two to share actions at a common site, the …

Reliable detection of disseminated tumor cells and of the biodistribution of tumor-targeting
therapeutic antibodies within the entire body has long been needed to better understand …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior
work has shown that brain cancers and metastases are densely infiltrated with anti …

The CRISPR/Cas9 system is an efficient genome-editing system that has been successfully
applied in the field of gene therapy. However, clinical applications of the CRISPR/Cas9 …

Targeted therapies and immunotherapy have brought substantial benefits to patients with
melanoma. However, brain metastases remain the biggest threat to the survival and quality …

Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel
through the vasculature and invade new tissues can remain in a non-proliferative dormant …

Purpose Almost all radiolabellings of antibodies with 89 Zr currently employ the hexadentate
chelator desferrioxamine (DFO). However, DFO can lead to unwanted uptake of 89 Zr in …

Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy
preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as …