Importance A previous meta-analysis of the association between alcohol use and all-cause
mortality found no statistically significant reductions in mortality risk at low levels of …

Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …

Wine is a traditional beverage that has been associated with both healthy and harmful
effects. Conceptions like the so-called “French paradox” or the beneficial impact of the …

This review discusses the inconsistent recommendations on alcohol consumption and its
association with chronic disease, highlighting the need for an evidence-based consensus …

In previous studies evaluating whether different alcoholic beverages would protect against
cardiovascular disease, a J-shaped relationship for increasing wine consumption and …

Dietary restriction (DR) delays or prevents age-related diseases and extends lifespan in
species ranging from yeast to primates. Although the applicability of this regimen to humans …

Flavonols are strong antioxidants in plant foods and tea is a major dietary source. There is
evidence from prospective cohort studies that tea and flavonols are inversely related to …

Background Cigarette smoking, adiposity, unhealthy diet, heavy alcohol drinking and
physical inactivity together are associated with about half of premature deaths in Western …

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse
biochemical and physiological properties, including estrogenic, antiplatelet, and anti …

SIRT1 is the closest mammalian homologue of enzymes that extend life in lower organisms.
Its role in mammals is incompletely understood, but includes modulation of at least 34 …