The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

Islet transplantation is a treatment for selected adults with type 1 diabetes and severe
hypoglycemia. Islets from two or more donor pancreases, a scarce resource, are usually …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

Islet transplantation holds significant promise as a curative approach for type 1 diabetes
(T1D). However, the transition of islet transplantation from the experimental phase to …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

In this minireview, we briefly outline the hallmarks of diabetes, the distinction between type 1
and type 2 diabetes, the global incidence of diabetes, and its associated comorbidities. The …

Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by
high blood glucose levels either due to an absolute deficiency of insulin secretion or an …