Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure

MP Shakarjian, DE Heck, JP Gray, PJ Sinko… - Toxicological …, 2010 - academic.oup.com
Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin,
eyes, and lung. It remains a significant military and civilian threat. The characteristic …

Mustard vesicating agent–induced toxicity in the skin tissue and silibinin as a potential countermeasure

N Tewari‐Singh, R Agarwal - Annals of the New York Academy …, 2016 - Wiley Online Library
Exposure to the vesicating agents sulfur mustard (SM) and nitrogen mustard (NM) causes
severe skin injury with delayed blistering. Depending upon the dose and time of their …

Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide–induced skin injury in SKH-1 hairless mice

N Tewari-Singh, S Rana, M Gu, A Pal… - Toxicological …, 2009 - academic.oup.com
Sulfur mustard (HD) is an alkylating and cytotoxic chemical warfare agent, which inflicts
severe skin toxicity and an inflammatory response. Effective medical countermeasures …

Histopathologic features seen with different animal models following cutaneous sulfur mustard exposure

KJ Smith, R Casillas, J Graham, HG Skelton… - Journal of …, 1997 - Elsevier
In an effort to understand the pathophysiology of sulfur mustard (2, 2′ dichlorodiethyl
sulfide, HD)-induced cutaneous lesions, a number of animal models have been used …

Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in …

AK Jain, N Tewari-Singh, M Gu, S Inturi, CW White… - Toxicology letters, 2011 - Elsevier
Bifunctional alkyalating agent, sulfur mustard (SM)-induced cutaneous injury is
characterized by inflammation and delayed blistering. Our recent studies demonstrated that …

Histopathologic and immunohistochemical features in human skin after exposure to nitrogen and sulfur mustard

KJ Smith, WJ Smith, T Hamilton… - The American journal …, 1998 - journals.lww.com
Abstract N-methyl-2, 2′-dichlorodiethylamine (HN 2) is a topical chemotherapeutic agent
used as therapy for cutaneous T-cell lymphomas (CTCL). Di (2-chloroethyl) sulfide (SM) …

2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin

AK Jain, N Tewari-Singh, DJ Orlicky, CW White… - Toxicology, 2011 - Elsevier
Sulfur mustard (HD) is a vesicating agent that has been used as a chemical warfare agent in
a number of conflicts, posing a major threat in both military conflict and chemical terrorism …

Topical iodine preparation as therapy against sulfur mustard-induced skin lesions

U Wormser, A Sintov, B Brodsky, A Nyska - Toxicology and applied …, 2000 - Elsevier
Sulfur mustard (SM) is a powerful vesicant employed as an agent of chemical warfare. This
study demonstrates the therapeutic effect of a novel topical iodine preparation as a …

Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite

DG Goswami, R Agarwal, N Tewari-Singh - Toxicology letters, 2018 - Elsevier
Abstract Phosgene Oxime (CX, Cl 2 CNOH), a halogenated oxime, is a potent chemical
weapon that causes immediate acute injury and systemic effects. CX, grouped together with …

[HTML][HTML] Role of NF-κB/RelA and MAPK pathways in keratinocytes in response to sulfur mustard

B Rebholz, K Kehe, T Ruzicka, RA Rupec - Journal of investigative …, 2008 - Elsevier
Sulfur mustard (SM) is a strong vesicant that has been used as a chemical warfare agent. To
understand the molecular mechanisms that underlie the inflammatory skin reaction in …