Abstract Purpose of Review Osteoarthritis is a complex and highly polygenic disease. Over
100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly …

Osteoarthritis (OA) is the most common degenerative joint disease. Multiple tissues are
altered during the development of OA, resulting in joint pain and permanent damage to the …

Background Osteoarthritis (OA) can lead to chronic joint pain, and currently there are no
methods available for complete cure. Utilizing the Gene Expression Omnibus (GEO) …

Background Facet joint osteoarthritis (FJOA) is a prevalent condition contributing to low back
pain, particularly in the elderly population. This study aimed to investigate the potential role …

Osteoporosis (OP), a prevalent skeletal disorder characterized by compromised bone
strength and increased susceptibility to fractures, poses a significant public health concern …

This review evaluates the current landscape and future directions of regenerative medicine
for knee cartilage repair, with a particular focus on tissue engineering strategies. In this …

Objective Obesity is a leading risk factor for both the incidence and progression of
osteoarthritis (OA). Omic technologies, including transcriptomics and metabolomics are …

Osteoarthritis (OA) is a prevalent degenerative condition among the elderly on a global
scale. Research has demonstrated that hypoxia can promote chondrocyte apoptosis and …

Background Primary knee osteoarthritis (KOA) is a heterogeneous disease with clinical and
molecular contributors. Biofluids contain microRNAs and metabolites that can be measured …

Methods Thirty-six individuals (mean age 63 years, 27 women) with KOA performed
baseline evaluations, and 16 (11 women) completed the one-year follow-up. All participants …