Therapeutic potential of certain terpenoids as anticancer agents: a scoping review

S Kamran, A Sinniah, MAM Abdulghani, MA Alshawsh - Cancers, 2022 - mdpi.com
Simple Summary Terpenoids are bioactive compounds with a variety of pharmacological
activities, including anticancer activity. This review paper aimed to focus on the anticancer …

Progress on Ras/MAPK signaling research and targeting in blood and solid cancers

M Dillon, A Lopez, E Lin, D Sales, R Perets, P Jain - Cancers, 2021 - mdpi.com
Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …

SHP-1/STAT3-signaling-axis-regulated coupling between BECN1 and SLC7A11 contributes to sorafenib-induced ferroptosis in hepatocellular carcinoma

CY Huang, LJ Chen, G Chen, TI Chao… - International Journal of …, 2022 - mdpi.com
Ferroptosis is a type of iron-dependent cell death pertaining to an excess of lipid
peroxidation. It has been suggested that sorafenib—an anti-angiogenic medication for …

GPX4 inhibition synergistically boosts mitochondria targeting nanoartemisinin-induced apoptosis/ferroptosis combination cancer therapy

H Yu, JM Li, K Deng, W Zhou, KH Li, CX Wang… - Biomaterials …, 2023 - pubs.rsc.org
Artemisinin, originally used for its antimalarial activity, has received much attention in recent
years for cancer therapy. The anticancer mechanisms of artemisinin are complicated and …

Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy

Z Ma, W Chen, Y Liu, L Yu, X Mao, X Guo, F Jiang… - Autophagy, 2024 - Taylor & Francis
Sorafenib is the most widely used first-line drug for the treatment of the advanced
hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its …

Roles of ferroptosis in urologic malignancies

S Zhao, P Li, W Wu, Q Wang, B Qian, X Li… - Cancer cell …, 2021 - Springer
Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly
contribute to the pathogenesis of multiple cancers. Recently, the positive association …

Pharmacokinetic and pharmacodynamic drug–drug interactions: research methods and applications

L Sun, K Mi, Y Hou, T Hui, L Zhang, Y Tao, Z Liu… - Metabolites, 2023 - mdpi.com
Because of the high research and development cost of new drugs, the long development
process of new drugs, and the high failure rate at later stages, combining past drugs has …

Repurposing artemisinin and its derivatives as anticancer drugs: a chance or challenge?

Z Ma, CYN Woon, CG Liu, JT Cheng, M You… - Frontiers in …, 2021 - frontiersin.org
Cancer has become a global health problem, accounting for one out of six deaths. Despite
the recent advances in cancer therapy, there is still an ever-growing need for readily …

An updated review on the potential antineoplastic actions of oleuropein

Y Zheng, Z Liu, X Yang, L Liu… - Phytotherapy Research, 2022 - Wiley Online Library
Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It
is a phenolic compound and the most luxuriant in olives. The detailed information related to …

Progress on the study of the anticancer effects of artesunate

X Yang, Y Zheng, L Liu, J Huang… - Oncology …, 2021 - spandidos-publications.com
Artesunate (ART) is a derivative of artemisinin that is extracted from the wormwood plant
Artemisia annua. ART is an antimalarial drug that has been shown to be safe and effective …