Acetaminophen (APAP) is a widely used analgesic and antipyretic over-the-counter
medicine worldwide. Hepatotoxicity caused by APAP overdose is one of the leading causes …

Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and
pyroptosis act as critical natural immune signaling axes for microbial infection, chronic …

Emodin, a substance extracted from herbs such as rhubarb, has a protective effect on the
central nervous system. However, the potential therapeutic effect of emodin in the context of …

Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

Acetaminophen (APAP) hepatotoxicity is an important cause of acute liver failure, resulting
in massive deaths in many developed countries. Currently, the metabolic process of APAP in …

The liver plays a vital role in metabolism, synthesis, and detoxification, but it is susceptible to
damage from various factors such as viral infections, drug reactions, excessive alcohol …

Hepatotoxicity brought on by acetaminophen (APAP) is significantly impacted by
mitochondrial dysfunction. Mitophagy, particularly PINK1-mediated mitophagy, maintains the …

Chronic inflammation induced by obesity plays a crucial role in the pathogenesis of insulin
resistance. The infiltration of macrophages into adipose tissues contributes to adipose tissue …

Triptolide (TP) exhibits therapeutic potential against multiple diseases. However, its
application in clinics is limited by TP-induced hepatoxicity. TP can activate invariant natural …

Hydroxyanthraquinones that can be present in traditional Chinese medicine (TCM) and
herbal extracts have claimed beneficial intestinal effects. We examined the ability of a panel …