[HTML][HTML] Dual role of the alternative reading frame ARF protein in cancer
The CDKN2a/ARF locus expresses two partially overlapping transcripts that encode two
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
14-3-3σ positively regulates p53 and suppresses tumor growth
HY Yang, YY Wen, CH Chen, G Lozano… - Molecular and cellular …, 2003 - Taylor & Francis
The 14-3-3σ (sigma) protein, a negative regulator of the cell cycle, is a human mammary
epithelium-specific marker that is downregulated in transformed mammary carcinoma cells …
epithelium-specific marker that is downregulated in transformed mammary carcinoma cells …
[HTML][HTML] A redox mechanism underlying nucleolar stress sensing by nucleophosmin
The nucleolus has been recently described as a stress sensor. The nucleoplasmic
translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; …
translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; …
[HTML][HTML] MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
Y Jin, H Lee, SX Zeng, MS Dai, H Lu - The EMBO journal, 2003 - embopress.org
The CDK inhibitor p21 waf1/cip1 is degraded by a ubiquitin‐independent proteolytic
pathway. Here, we show that MDM2 mediates this degradation process. Overexpression of …
pathway. Here, we show that MDM2 mediates this degradation process. Overexpression of …
UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis
JC Ehrhart, FP Gosselet, RM Culerrier… - Photochemical & …, 2003 - pubs.rsc.org
The UVB component of the solar spectrum induces DNA lesions that, in the absence of error-
free DNA repair, may give rise during DNA replication to mutations in caretaker and …
free DNA repair, may give rise during DNA replication to mutations in caretaker and …
[HTML][HTML] Oncomir miR-125b Suppresses p14ARF to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer
S Amir, AH Ma, XB Shi, L Xue, HJ Kung… - PloS one, 2013 - journals.plos.org
MicroRNAs are a class of naturally occurring small non-coding RNAs that target protein-
coding mRNAs at the post-transcriptional level and regulate complex patterns of gene …
coding mRNAs at the post-transcriptional level and regulate complex patterns of gene …
[HTML][HTML] Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism
Inhibition of the MDM2-p53 feedback loop is critical for p53 activation in response to cellular
stresses. The ribosomal proteins L5, L11, and L23 can block this loop by inhibiting MDM2 …
stresses. The ribosomal proteins L5, L11, and L23 can block this loop by inhibiting MDM2 …
Detecting Homozygous Deletions in the CDKN2A(p16INK4a)/ARF(p14ARF) Gene in Urinary Bladder Cancer Using Real-Time Quantitative PCR
P Berggren, R Kumar, S Sakano, L Hemminki… - Clinical cancer …, 2003 - AACR
Purpose: 9p21 is a major target in the pathogenesis of human urinary bladder cancer. The
locus harbors the CDKN2A/ARF tumor suppressor gene, which encodes two cell cycle …
locus harbors the CDKN2A/ARF tumor suppressor gene, which encodes two cell cycle …
[HTML][HTML] Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay
EM McGowan, N Alling, EA Jackson, D Yagoub… - PloS one, 2011 - journals.plos.org
Endocrine resistance is a major problem with anti-estrogen treatments and how to overcome
resistance is a major concern in the clinic. Reliable measurement of cell viability …
resistance is a major concern in the clinic. Reliable measurement of cell viability …
Absence of p16INK4a and truncation of ARF tumor suppressors in chickens
SH Kim, M Mitchell, H Fujii… - Proceedings of the …, 2003 - National Acad Sciences
The INK4b-ARF-INK4a locus on human chromosome 9p21 (Human Genome Organization
designation CDKN2B-CDKN2A), and the corresponding locus on mouse chromosome 4 …
designation CDKN2B-CDKN2A), and the corresponding locus on mouse chromosome 4 …