Organocatalytic asymmetric synthesis of indole-based chiral heterocycles: strategies, reactions, and outreach

YC Zhang, F Jiang, F Shi - Accounts of chemical research, 2019 - ACS Publications
Conspectus Indole-based chiral heterocycles constitute a class of important heterocyclic
compounds that are found in numerous pharmaceuticals, functional materials, and chiral …

Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

From C4 to C7: Innovative strategies for site-selective functionalization of indole C–H bonds

J Wen, Z Shi - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus The widespread presence of hydrocarbons makes C–H functionalization an
attractive alternative to traditional cross-coupling methods. As indole is an important …

Progresses in organocatalytic asymmetric dearomatization reactions of indole derivatives

FT Sheng, JY Wang, W Tan, YC Zhang… - Organic Chemistry …, 2020 - pubs.rsc.org
Chiral indole derivatives such as indolines and indolenines are important heterocyclic
frameworks which constitute the core structures of many natural products and bioactive …

Metal-mediated and metal-catalyzed reactions under mechanochemical conditions

A Porcheddu, E Colacino, L De Luca, F Delogu - ACS Catalysis, 2020 - ACS Publications
The extraordinary impact of metal-based complexes on synthetic methods is still recognized
nowadays, and attempts are currently undertaken to further extend the use of metal-assisted …

Porous organic polymers: a promising platform for efficient photocatalysis

T Zhang, G Xing, W Chen, L Chen - Materials Chemistry Frontiers, 2020 - pubs.rsc.org
Porous organic polymers (POPs) are a class of multi-dimensional porous network materials,
which are built via strong covalent linkages between various organic building blocks with …

Asymmetric (4+ n) Cycloadditions of Indolyldimethanols for the Synthesis of Enantioenriched Indole‐Fused Rings

JY Zhang, JY Chen, CH Gao, L Yu… - Angewandte Chemie …, 2023 - Wiley Online Library
Catalytic asymmetric construction of chiral indole‐fused rings has become an important
issue in the chemical community because of the significance of such scaffolds. In this work …

Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective

E Vitaku, DT Smith, JT Njardarson - Journal of medicinal chemistry, 2014 - ACS Publications
Nitrogen heterocycles are among the most significant structural components of
pharmaceuticals. Analysis of our database of US FDA approved drugs reveals that 59% of …

Indoles—A promising scaffold for drug development

TV Sravanthi, SL Manju - European Journal of Pharmaceutical Sciences, 2016 - Elsevier
Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …

Late transition metal-catalyzed hydroamination and hydroamidation

L Huang, M Arndt, K Gooßen, H Heydt… - Chemical …, 2015 - ACS Publications
This Review examines recent developments in late transition metal-catalyzed
hydroamination and-amidation reactions. A hydroamination is a reaction in which an N− H …