Aneuploidy and complex genomic rearrangements in cancer evolution
Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …
tumors. They range from simple copy number gains and losses to the shattering and …
Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
BCMA targeting chimeric antigen receptor (CAR) T cell therapy has shown deep and
durable responses in multiple myeloma. However, relapse following therapy is frequently …
durable responses in multiple myeloma. However, relapse following therapy is frequently …
The complex karyotype in hematological malignancies: a comprehensive overview by the Francophone Group of Hematological Cytogenetics (GFCH)
F Nguyen-Khac, A Bidet, A Daudignon… - Leukemia, 2022 - nature.com
Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …
Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through …
W Li, B Zhang, W Cao, W Zhang, T Li, L Liu… - … Hematology & Oncology, 2023 - Springer
Abstract Background BCMA CAR-T is highly effective for relapsed/refractory multiple
myeloma (R/R-MM) and significantly improves the survival of patients. However, the short …
myeloma (R/R-MM) and significantly improves the survival of patients. However, the short …
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis
Z Hua, R Wei, M Guo, Z Lin, X Yu, X Li, C Gu, Y Yang - Oncogene, 2022 - nature.com
Multiple myeloma (MM) is still incurable partially due to lacking effective therapeutic targets.
Aberrant N6-methyladenosine (m6A) RNA modification plays a vital role in many cancers …
Aberrant N6-methyladenosine (m6A) RNA modification plays a vital role in many cancers …
AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma
T Bruno, G Corleone, V Catena, C Cortile… - The EMBO …, 2022 - embopress.org
Several kinds of stress promote the formation of three‐stranded RNA: DNA hybrids called R‐
loops. Insufficient clearance of these structures promotes genomic instability and DNA …
loops. Insufficient clearance of these structures promotes genomic instability and DNA …
Genetic abnormalities in extramedullary multiple myeloma
R McAvera, J Quinn, P Murphy, S Glavey - International Journal of …, 2023 - mdpi.com
Extramedullary multiple myeloma (or extramedullary disease, EMD) is an aggressive form of
multiple myeloma (MM) that occurs when malignant plasma cells become independent of …
multiple myeloma (MM) that occurs when malignant plasma cells become independent of …
Pathogenesis and treatment of multiple myeloma
P Yang, Y Qu, M Wang, B Chu, W Chen, Y Zheng… - MedComm, 2022 - Wiley Online Library
Multiple myeloma (MM) is the second‐ranking malignancy in hematological tumors. The
pathogenesis of MM is complex with high heterogeneity, and the development of the …
pathogenesis of MM is complex with high heterogeneity, and the development of the …
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs
I Saltarella, A Lamanuzzi, V Desantis… - The Journal of …, 2022 - Wiley Online Library
Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between
MM cells and bone marrow (BM) fibroblasts (FBs). During monoclonal gammopathy of …
MM cells and bone marrow (BM) fibroblasts (FBs). During monoclonal gammopathy of …
[HTML][HTML] Advancing therapeutic strategies for Epstein-Barr virus-associated malignancies through lytic reactivation
H Tan, Y Gong, Y Liu, J Long, Q Luo, OD Faleti… - Biomedicine & …, 2023 - Elsevier
Epstein-Barr virus (EBV) is a widespread human herpes virus associated with lymphomas
and epithelial cell cancers. It establishes two separate infection phases, latent and lytic, in …
and epithelial cell cancers. It establishes two separate infection phases, latent and lytic, in …