The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Rapid advances in the isolation of multipotent progenitor cells, routinely called
mesenchymal stromal/stem cells (MSCs), from various human tissues and organs have …

It was shown as long as half a century ago that bone marrow is a source of not only
hematopoietic stem cells, but also stem cells of mesenchymal tissues. Then the term …

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament
initially characterized in neural stem cells. However, current extensive evidence obtained in …

Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …