Cerebral dysfunctions caused by sepsis during ageing

T Manabe, MT Heneka - Nature Reviews Immunology, 2022 - nature.com
Systemic inflammation elicited by sepsis can induce an acute cerebral dysfunction known as
sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common …

Sepsis: pathophysiology and clinical management

JE Gotts, MA Matthay - Bmj, 2016 - bmj.com
Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

[HTML][HTML] Focus: Death: Organ dysfunction in sepsis: An ominous trajectory from infection to death

C Caraballo, F Jaimes - The Yale journal of biology and medicine, 2019 - ncbi.nlm.nih.gov
Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Sepsis-associated encephalopathy and septic encephalitis: an update

SC Tauber, M Djukic, J Gossner, H Eiffert… - Expert review of anti …, 2021 - Taylor & Francis
Introduction Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are
associated with increased mortality, long-term cognitive impairment, and focal neurological …

[HTML][HTML] Septic-associated encephalopathy: a comprehensive review

A Mazeraud, C Righy, E Bouchereau, S Benghanem… - …, 2020 - Elsevier
Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from
delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is …

Sepsis-associated encephalopathy: from delirium to dementia?

HY Chung, J Wickel, FM Brunkhorst, C Geis - Journal of clinical medicine, 2020 - mdpi.com
Sepsis is a major cause of death in intensive care units worldwide. The acute phase of
sepsis is often accompanied by sepsis-associated encephalopathy, which is highly …

Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

N Sekino, M Selim, A Shehadah - Journal of Neuroinflammation, 2022 - Springer
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Sepsis‐induced brain dysfunction: pathogenesis, diagnosis, and treatment

S Pan, Z Lv, R Wang, H Shu, S Yuan… - … medicine and cellular …, 2022 - Wiley Online Library
Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

C Ren, R Yao, H Zhang, Y Feng, Y Yao - Journal of neuroinflammation, 2020 - Springer
Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions,
and is responsible for increased mortality and poor outcomes in septic patients …

Sepsis-associated encephalopathy

TE Gofton, GB Young - Nature Reviews Neurology, 2012 - nature.com
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs
secondary to infection in the body without overt CNS infection. SAE is frequently …