Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants

WR Strohl, Z Ku, Z An, SF Carroll, BA Keyt, LM Strohl - BioDrugs, 2022 - Springer
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …

Prevention of Congenital Cytomegalovirus Infection: Review and Case Series of Valaciclovir versus Hyperimmune Globulin Therapy

G Nigro, M Muselli… - Viruses, 2023 - mdpi.com
Cytomegalovirus (CMV) is the most common cause of congenital infections in developed
countries because is capable of infecting the fetus after both primary and recurrent maternal …

A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection

W Tai, K Yang, Y Liu, R Li, S Feng, B Chai… - Nature …, 2023 - nature.com
The respiratory system, especially the lung, is the key site of pathological injury induced by
SARS-CoV-2 infection. Given the low feasibility of targeted delivery of antibodies into the …

Can the SARS-CoV-2 omicron variant confer natural immunity against COVID-19?

AH Abas, S Marfuah, R Idroes, D Kusumawaty… - Molecules, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, with no signs of
abatement in sight. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Efficacy of COVID-HIGIV in animal models of SARS-CoV-2 infection

A Jha, D Barker, J Lew, V Manoharan, J van Kessel… - Scientific reports, 2022 - nature.com
In late 2019 the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus
emerged in China and quickly spread into a worldwide pandemic. It has caused millions of …

Transchromosomic bovines‐derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on …

ARA Saied, MSL Nascimento… - Journal of medical …, 2022 - Wiley Online Library
Historically, passive immunotherapy is an approved approach for protecting and treating
humans against various diseases when other alternative therapeutic options are …

Neonatal sepsis and transient immunodeficiency: Potential for novel immunoglobulin therapies?

CR Beudeker, DC Vijlbrief, JM van Montfrans… - Frontiers in …, 2022 - frontiersin.org
Neonates, especially preterm neonates, have the highest risk of sepsis of all age groups.
Transient immaturity of the neonatal immune system is an important risk factor. Neonates …

SIR+ models: accounting for interaction-dependent disease susceptibility in the planning of public health interventions

MM Martignoni, A Raulo, O Linkovski, O Kolodny - Scientific Reports, 2024 - nature.com
Avoiding physical contact is regarded as one of the safest and most advisable strategies to
follow to reduce pathogen spread. The flip side of this approach is that a lack of social …

Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

L Oestereich, H Müller-Kräuter, E Pallasch, T Strecker - Viruses, 2023 - mdpi.com
Background: Lassa virus (LASV) can cause severe acute systemic infection in humans. No
approved antiviral drugs or vaccines are currently available. Antibody-based therapeutics …

Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase

KE Ramos, NMA Okba, J Tan, P Bandawane… - mBio, 2024 - Am Soc Microbiol
Monoclonal antibodies (mAbs) are an attractive therapeutic platform for the prevention and
treatment of influenza virus infection. There are two major glycoproteins on the influenza …