Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Actinomycetes are historically important sources for secondary metabolites (SMs) with
applications in human medicine, animal health, and plant crop protection. It is now clear that …

Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …

Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and
structurally diverse secondary metabolites in nature with many possessing bioactivity that …

There is a continuous need for antibiotics, mainly with new mechanisms of action, since
infectious diseases represent the second major cause of death in the world and bacteria …

Microbially derived natural products are major sources of antibiotics and other medicines,
but discovering new antibiotic scaffolds and increasing the chemical diversity of existing …

Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …

Glycopeptides are considered antibiotics of last resort for the treatment of life-threatening
infections caused by relevant Gram-positive human pathogens, such as Staphylococcus …

For decades, microbial natural products have been one of the major sources of novel drugs
for pharmaceutical companies, and today all evidence suggests that novel molecules with …

Secondary metabolites from microorganisms have a broad spectrum of applications,
particularly in therapeutics. The growing number of sequenced microbial genomes has …