Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having
multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high …

Infectious diseases along with various cancer types are among the most significant public
health problems and the leading cause of death worldwide. The situation has become even …

Here, we investigated the possible anti-cancer properties of bromelain in Kras mutant
human colorectal carcinoma cell lines and a mouse model harboring a Kras mutation. Cell …

Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …

In microbial cultures the production of secondary metabolites is affected by experimental
conditions, and the discovery of novel compounds is often prevented by the re-isolation of …

Background Colon cancer treatments include surgery, radiotherapy, and chemotherapy.
Chemotherapy using 5-fluorouracil (5-FU) has been widely applied to treat colorectal cancer …

Dense extracellular matrix (ECM) is a primary obstacle that restrains the permeation of
therapeutic drugs in tumor tissues. Degrading ECM with bromelain (Br) to increase drug …

This study reports on the development of a scaffold with a gradient of bioactive solid signal
embedded in the biodegradable polymer matrix by combining a sol–gel approach and …

The aim of this study was to investigate the molecular, biochemical, and histopathological
effects of bromelain, which has antioxidant and anti-inflammatory properties, against …

Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …