Thailand is located in the tropics and a wide variety of fruits are grown commercially.
However, studies regarding the phytonutrients, anti-mutagenic and chemopreventive effects …

Cholangiocarcinoma (CC) worldwide is the most common biliary malignancy with poor
prognostic value and new systemic treatments are desirable. Plant extracts like bromelain …

For centuries, bromelain has been used to treat a range of ailments, even though its
mechanism of action is not fully understood. Its therapeutic benefits include enzymatic …

Tumor extracellular matrix (ECM) still remains a major barrier that hinders the diffusion of
drug in tumor parenchyma. We design a lactobionic acid (LA) and bromelain dual-functional …

Despite the remarkable advancement in the health care sector, cancer remains the second
most fatal disease globally. The existing conventional cancer treatments primarily include …

Purpose This study was conducted a promising approach to surface functionalization
developed for lipid-core nanocapsules and the merit to pursue new strategies to treat solid …

In the last years, colorectal cancer (CRC) has been increasing substantially in developing
countries. While the consumption of fat and meat have been linked with increased CRC risk …

The pineapple, botanically named Ananas comosus, has been used for centuries as a folk
medicine by the indigenous inhabitants of Central and South America. The medicinal …

Chlorophyllide (chlide) is a natural catabolic product of chlorophyll (Chl), produced through
the activity of chlorophyllase (chlase). The growth inhibitory and antioxidant effects of chlide …

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was
encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of …