As immune regulators, cytokines serve critical role as signaling molecules in response to
danger, tissue damage, or injury. Importantly, due to their vital role in immunological …

Simple Summary Tumor-associated neutrophils (TANs) may differentiate into different
patterns under the stimulation of different factors, and they play a dual role in the occurrence …

Colorectal cancer (CRC) is considered the second cause of cancer death worldwide. The
early diagnosis plays a key role in patient prognosis and subsequently overall survival …

Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic
changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As …

Immunotherapies have emerged as promising strategies for cancer treatment. However,
existing immunotherapies have poor activity in high-grade serous ovarian cancer (HGSC) …

Neutrophils, the most copious leukocytes in human blood, play a critical role in
tumorigenesis, cancer progression, and immune suppression. Recently, neutrophils have …

Neutrophils are the most abundant immune cells and make up about 70% of white blood
cells in human blood and play a critical role as the first line of defense in the innate immune …

The clearance of apoptotic cells known as efferocytosis is the final stage of apoptosis, and
includes the recognition, phagocytosis, and degradation of apoptotic cells. The maintenance …

Abstract Background Tumor-associated macrophages (TAMs) are major component in the
tumor microenvironment (TME) and play regulatory role in tumor progression. We aimed to …

Background Epirubicin/cyclophosphamide (EC) and docetaxel (D) are commonly used in a
sequential regimen in the neoadjuvant treatment of early, high-risk or locally advanced …