CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
CGRP as the target of new migraine therapies—successful translation from bench to clinic
L Edvinsson, KA Haanes, K Warfvinge… - Nature Reviews …, 2018 - nature.com
Abstract Treatment of migraine is on the cusp of a new era with the development of drugs
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …
Migraine and the trigeminovascular system—40 years and counting
The underlying causes of migraine headache remained enigmatic for most of the 20th
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …
CGRP and the trigeminal system in migraine
S Iyengar, KW Johnson, MH Ossipov… - … : The Journal of Head …, 2019 - Wiley Online Library
Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin,
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
Meningeal mechanisms and the migraine connection
D Levy, MA Moskowitz - Annual review of neuroscience, 2023 - annualreviews.org
Migraine is a complex neurovascular pain disorder linked to the meninges, a border tissue
innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal …
innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal …
Fremanezumab—a humanized monoclonal anti-CGRP antibody—inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
afferent sensory neurons, is strongly implicated in the pathophysiology of migraine …
Current understanding of trigeminal ganglion structure and function in headache
K Messlinger, AF Russo - Cephalalgia, 2019 - journals.sagepub.com
Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …
its topography, structure, composition and possibly some functional properties of its cellular …
Dual therapy with anti‐CGRP monoclonal antibodies and botulinum toxin for migraine prevention: is there a rationale?
Objective To narratively review the pathophysiological rationale of dual therapy with anti‐
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …