Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …

Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in western
countries. APAP can cause extensive hepatocellular necrosis, which triggers an …

Abstract Background Cirsii Japonici Herba Carbonisata (Dajitan in Chinese) has been used
to treat liver disorders in Asian countries. Pectolinarigenin (PEC), an abundant constituent in …

Significance: Acetaminophen (APAP) is one of the quantitively most consumed drugs
worldwide. Although safe at therapeutic doses, intentional or unintentional overdosing …

Abstract Background Carbon tetrachloride (CCl 4) is a well-characterized hepatotoxic agent.
With rising cases of liver diseases, the identification, assessment, and development of …

Acetaminophen (APAP) overdose can cause severe liver injury and acute liver failure. The
only clinically approved antidote, N‐acetylcysteine (NAC), is highly effective but has a …

Introduction Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure
in the western world. Despite extensive investigations into the mechanisms of cell death …

Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the
western world. Oridonin (OD), which is the major active ingredient of the traditional Chinese …

The current study aims at repurposing the anti-arthritic drug diacerein (DCN) for the
treatment of acetaminophen hepatotoxicity and investigating the potential underlying …